Opioid Receptor Agonist

Opioid Receptor Agonists (145):

Cat. No.	Product Name	Effect	Purity

HY-B0418A

Loperamide hydrochloride	Agonist	99.90%
Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist. Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect.

HY-P0183

Nociceptin	Agonist	98.70%
Nociceptin, a heptadecapeptide, is the endogenous ligand of the nociceptin receptor, acting as a potent anti-analgesic.

HY-15536

Cebranopadol	Agonist	98.46%
Cebranopadol is an analgesic NOP and opioid receptor agonist with K_is/EC₅₀s of 0.9 nM/13 nM, 0.7 nM/1.2 nM, 2.6 nM/17 nM, 18 nM/110 nM for human NOP, MOP, KOP and delta-opioid peptide (DOP) receptor, respectively.

HY-105343

BW-180C	Agonist	99.92%
BW-180C ([D-Ala2, D-Leu5]-Enkephalin; DADLE) is an δ opioid receptor (DOR) agonist, which belongs to the enkephalin family. Neuroprotective agent. BW-180C reversibly inhibits cellular transcription in neurons without causing cell injury.

HY-15997B

(±)-U-50488 hydrochloride	Agonist	99.73%
(±)-U-50488 ((±)-Trans-(1R,2R)-U-50488) hydrochloride is a selective κ opioid receptor (KOR) agonist.

HY-128865

BPR1M97	Agonist	98.32%
BPR1M97 is a dual-acting mu opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist with K_i values of 1.8 and 4.2 nM, respectively. BPR1M97 shows high potency and blood-brain barrier penetration, and produces potent antinociceptive effects.

HY-13716

Noscapine	Agonist	98.70%
Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier.

HY-124959

Spiradoline mesylate	Agonist	99.95%
Spiradoline mesylate (U-62066 mesylate), an arylacetamide, is a selective kappa opioid receptor (KOR) agonist with a K_i of 8.6 nM in guinea pig. The K_i values of Spiradoline mesylate for μ and δ receptors are 252 nM and 9400 nM, respectively. Spiradoline mesylate has potent diuretic, analgesic, antiarrythmic, antitussive, neuroprotective properties and easily penetrates the blood-brain barrier.

HY-P0179

β-Casomorphin, bovine	Agonist	99.89%
β-Casomorphin, bovine (β-Casomorphin-7 (bovine) ) is a opioid peptide with an IC₅₀ of 14 μM in an Opioid receptors binding assay.

HY-P3870A

DALDA acetate	Agonist	99.53%
DALDA acetate is a potent and highly selective μ-opioid receptor agonist with a K_i of 1.69 nM. DALDA acetate shows antinociceptive and respiratory effects.

HY-107747

GR 89696	Agonist	99.88%
GR 89696 is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus.

HY-B0418AR

Loperamide (hydrochloride) (Standard)	Agonist	99.89%
Loperamide (hydrochloride) (Standard) is the analytical standard of Loperamide (hydrochloride). This product is intended for research and analytical applications. Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist. Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect.

HY-107741

SNC162	Agonist	99.72%
SNC162 is a delta-opioid receptor agonist with an IC₅₀ of 0.94 nM. SNC162 has antidepressant-like effects and produces a selective enhancement of the antinociceptive effects of fentanyl in rhesus monkeys.

HY-120949

(1R,2R)-U-50488 hydrochloride	Agonist	99.14%
(1R,2R)-U-50488 hydrochloride is the absolute stereochemistry of (±)-U-50488 hydrochloride. (±)-U-50488 hydrochloride is a selective κ opioid receptor (KOR) agonist.

HY-13101

MCOPPB trihydrochloride	Agonist	99.89%
MCOPPB trihydrochloride is a nociceptin receptor agonist with pKi of 10.

HY-P1337

Dynorphin B (1-13)	Agonist	98.09%
Dynorphin B (1-13) acts as an agonist on opioid κ-receptor.

HY-P1470

[Leu5]-Enkephalin, amide	Agonist
[Leu5]-Enkephalin, amide is a δ opioid receptor agonist.

HY-134189A

EST73502 monohydrochloride	Agonist	99.58%
EST73502 monohydrochloride is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with K_is of 64 nM and 118 nM for MOR and σ1R, respectively. EST73502 monohydrochloride has antinociceptive activity.

HY-101079

BRL 52537 hydrochloride	Agonist	98.14%
BRL 52537 hydrochloride is a highly selective κ-Opioid receptor (KOR) agonist with K_is of 0.24 nM and 1560 nM for κ and μ subtypes, respectively. BRL 52537 hydrochloride decreases ischemia-evoked NO production as a potential mechanism of neuroprotection. BRL 52537 hydrochloride attenuates early stroke damage.

HY-123534

CYT-1010	Agonist	99.74%
CYT-1010 is a mu-opioid receptor agonist extracted from patent WO2013173730A2, with EC₅₀s of 13.1 nM and 0.0053 nM on beta-arrestin recruitment and inhibition of cAMP production, respectively.

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